DAVID ALBERTINI, PhD
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David Albertini, PhD MS |
Bedford Research Foundation (BRF) |
Professor David Albertini
Biography/ Background
David Albertini received his Ph.D. from Harvard University working on the cell biology of the mammalian ovary. After postdoctoral work at the University of Connecticut Health Center, he returned to Harvard Medical School as an Assistant Professor of Anatomy and Cell Biology until 1984. He served as Professor at Tufts University Schools of Medicine up to 2004, was Chair of the Department of Anatomy and Cell Biology (1996-2000), Director of the Center for Reproduction (1999-2003) and Director of the Confocal Microscopy core (1988-1999). From 2004-2014, he was the Hall Professor of Molecular Medicine (Endowed Chair) at the Kansas University Medical Center where he continued his career long interests in the link between oocyte and embryo quality, especially as it pertains to the practice of human Assisted Reproduction Technologies. From 2014-2019 he was Director of Laboratories and Senior Scientist at The Center for Human Reproduction in New York City and continues to hold a Visiting Scientist appointments at the CHR and The Rockefeller University. Since 2009, he has served as Editor-in-Chief of the Journal of Assisted Reproduction and Genetics, an official journal of the American Society for Reproductive Medicine since 2009. In 2020 he joined the Bedford Research Foundation where he is continuing his work on stem cells and women’s health (https://mailchi.mp/bedfordresearch/support-stem-cell-research-today-4730630?e=563da5fecc). He is the recipient of many awards including a Basil O’Connor fellowship from the March of Dimes, the Hammond Medal from the Society for Reproduction and Fertility (UK), and Founder’s Lectureship for the Australian Society of Reproductive Biology and is a Fellow of The International Society for In Vitro Fertilization. Professor Albertini has delivered more than 200 lectures worldwide and has served on scientific advisory boards or grant review councils in Australia, Belgium, Denmark, Scotland, Portugal, Ireland, Italy and the USA.
Education
1970 - BSc Biology, Marquette University (mentor: Anthony P. Mahowald)
1972 - MSc, Zoology, University of Massachusetts-Amherst (mentor: Everett Anderson)
1975 – PhD, Anatomy and Cell Biology, Harvard University (mentors: Everett Anderson and Don W. Fawcett)
1975-1977-Postdoctoral Fellow, Physiology and Biophysics, University of Connecticut Health Center(mentor: Richard D. Berlin)
Positions Held
1972-1975
NIH Pre-doctoral fellow, Anatomy Department, Harvard Medical School, Boston, MA
1976-1977
NIH Post-doctoral fellow, Physiology Department, Univ. Conn. Health Center, Farmington, CT
1977-1983 Assistant Professor, Dept. Anatomy; Member, Laboratory of Human Reproduction and Reproductive Biology and Program in Cell and Developmental Biology, Harvard Medical School, Boston, MA
1984-1993 Associate Professor of Anatomy and Cellular Biology, Tufts Univ. School of Medicine, Boston, MA
1991 Visiting Scientist, UMASS Medical Center; Anatomy Cell Biology and Physiology Sabbatical (with Fred Fay and Rob Singer)
1993-2004 Professor of Anatomy and Cellular Biology, and Obstetrics and Gynecology, Tufts University Schools of Medicine, Boston, MA
1999-2003 Chair, Department of Anatomy and Cellular Biology, Tufts University School of Medicine
2001-2003 Director, NIH P30 Center for Reproductive Sciences, Tufts University
1995-2002 Board of Directors, Serono Ovarian Workshop, Member (Chair 2001)
1993-2004 Lecturer in Pathology, Harvard Medical School, Boston, MA
1992-2004 Associate Scientist, New England Regional Primate Research Center, Southborough, MA
2004-2008 Frontiers in Reproduction, Course Co-Director, Marine Biological laboratory; Whitman Fellow
2003-2004 Visiting Scientist, Laboratory of Reproductive Medicine. Marine Biological Laboratories, Woods Hole MA. Dr David Keefe (mentor)
2004-2016 Hall Professor of Molecular Medicine, Molecular and Integrative Physiology, Anatomy and Cell Biology, Obstetrics and Gynecology, University of Kansas Medical Center
2006-present Member, Marine Biological Laboratory Corporation
2000-2012 Associate Editor, Human Reproduction (2003-2006), Reproduction (2005-2008), Molecular Reproduction and Development (2002-2005), Fertility and Sterility (2003-2008), Zygote (2011-present)
2009-present Editor-in-Chief, Journal of Assisted Reproduction and Genetics
2014-2019 Director of Laboratories, Senior Scientist, The Center for Human Reproduction NY
2012-2014 Section Editor “Gametes and Embryos” in 4th Edition Knobil and Neill’s Physiology of Reproduction, Editors-in-Chief Tony M. Plant and Anthony J. Zeleznik
2016-present Visiting Scientist The Rockefeller University and CHR
Awards & Achievements
2018 Honorary Fellow, International Society for In Vitro Fertilization
2016 D.H. Barron Lectureship, University of Florida
2013 Beacon Award, Frontiers of Reproduction, MBL (shared with Teresa Woodruff)
2011 Deutsch Memorial Lectureship in Reproductive Medicine, Wayne State University
2003 Colwin Fellow, Marine Biological Laboratory, Woods Hole
2001 Founder’s Lecturer, Australian Society of Reproductive Biology
1999 Hammond Medal Recipient, Society for Reproduction and Fertility (UK)
1980 Basil O’Connor Fellow, National Foundation March of Dimes
1978 – Whittaker Health Sciences and Technology Fellow, Harvard-MIT HST Program
1976 – NIH Postdoctoral Fellowship, University of Connecticut Health Center (mentor, Richard D. Berlin, M.D.)
1972 – NIH Predoctoral Fellowship, T32 Training Grant, Harvard Medical School (mentor, Everett Anderson, PhD)
1969- NIH Summer Research Fellowship, Harvard Medical School, NERPRC (mentor, Arthur T. Hertig, M.D.)
Research Interests
Women’s Health
Oogenesis, Embryogenesis
Ovarian Physiology and Reproductive Endocrinology
Assisted Reproduction and Fertility Preservation
Stem Cells in Reproductive Medicine
Cytoskeleton and Cell Cycle
Editorial Boards
Current: Zygote, Reproductive Medicine and Society
Past: Human Reproduction, Reproduction, Molecular Reproduction and Development
Meeting Organizing Committees
Ovarian Club, II-VI, 2011-2016
Foundation for Reproductive Medicine 2016 (//frm.cme-congresses.com/conference-program.aspx)
ESHRE Workshops 2014-2018
ESHRE Capri Workshops 2013-2019
Teaching (Harvard, Tufts, UMASS-MED, MBL, KUMC)
>40 Years of Course Conception, Directorship and Lecturing: Professional Schools: Gross Anatomy,Embryology,Cell Biology,Histology; Graduate Level: Reproductive Physiology, Cell Biology, Developmental Biology, Biomedical Imaging, Grant Writing Skills
Publications (Google Scholar H Index=63, >15,000citations)
Books: Oogenesis (2013) Editors: Cotichhio, G., Albertini, D.F., and DeSantis, L. Springer. ISBN: 978-0-85729-825-6 (Print) 978-0-85729-826-3 (Online); DOI 10.1007/978-0-85729-826.
Recent Publications (selected since 2010)
Place, NJ, Prado, AM, Faykoo-Martinez, M, Brieno-Enriques, MAS, Albertini, DF, and Holmes, MM.2020. Germ cell nests in adult ovaries and an unusually large ovarian reserve in the naked mole-rat. Reprod 161:89-98. https://doi.org/10.1530/REP -20-0304
Bebbere, D.Abazari-Kia, A.Nieddu, S.Melis Murgia, B.Albertini, D. F.Ledda, S. 2020.
Subcortical maternal complex (SCMC) expression during folliculogenesis is affected by oocyte donor age in sheep J Assist Reprod Genet 37:2259 10.1007/s10815-020-01871.
Gleicher, N, Albertini, DF, Barad, DH et.al., 2020. The 2019 PGDIS position statement on transfer of mosaic embryos within a context of new information on PGT-A Reprod Biol Endocrinol 18:57; 10.1186/s12958-020-00616.
Gleicher, N.,Darmon, S.,Molinari, E.,Zhang, L,.Hu, J.,Albertini, D. F.,Barad, D. H. 2020.
A form of secondary ovarian insufficiency (SOI) due to adrenal hypoandrogenism as new infertility diagnosis Endocrine 10.1007/s12020-020-02512.
Weghofer, A.,Barad, D. H.,Darmon, S. ,K.Kushnir, V. A.,Albertini, D. F.,Gleicher, N.
2020. The ovarian sensitivity index is predictive of live birth chances after IVF in infertile patients Hum Reprod Open 10.1093/hropen/hoaa049.
Weghofer, A.,Barad, D. H.,Darmon, S. K.,Kushnir, V.A.,Albertini, D. F.Gleicher, N.
2020. Euploid miscarriage is associated with elevated serum C-reactive protein levels in infertile women: a pilot study. Arch Gynecol Obstet 301;801; 10.1007/s00404-020-05461
Albertini, DF 2019. Prospects for new oocyte-based assisted reproduction in animals and humans. Reprod Fertil Dev, 32:7, 10.1071/RD19271.
Patrizio, P, Albertini, DF 2019. Old is bad, young is good, but what about very young? Oocytes obtained from pre-pubertal ovarian tissue of very young patients are incapable of in vitro maturation Fertil Ster 112:239, 10.1016/j.fertnstert.2019.05.002.
Weghofer, A., Kushnir, VA, Darmon, SK, ….Albertini, DF, Barad, DH, Gleicher, N. 2019. Age, body weight and ovarian function affect oocyte size and morphology in non-PCOS patients undergoing intracytoplasmic sperm injection (ICSI) PLoS One 10.1371/journal.pone.0222390
Kushnir VA, Barad DB, Albertini DF, Darmon S, Gleicher N. Systematic review of worldwide trends in assisted reproductive technology 2004-2013. Reprod Biol Endocrinol. 2017 Jan 10;15(1):6. doi: 10.1186/s12958-016-0225-2.
McLaughlin, M.,Albertini, D. F.,Wallace, W. H. B.,Anderson, R. A.Telfer, E.E. 2018. Metaphase II oocytes from human unilaminar follicles grown in a multi-step culture system. Mol Hum Reprod 24:135. 10.1093/molehr/gay002.
Kushnir VA, Darmon SK, Albertini DF, Barad DH, Gleicher N. Effectiveness of in vitro fertilization with preimplantation genetic screening: a reanalysis of United States assisted reproductive technology data 2011-2012. Fertil Steril. 2016 Jul;106(1):75-9. doi: 10.1016/j.fertnstert.2016.02.026.
Kushnir VA, Darmon SK, Shapiro AJ, Albertini DF, Barad DH, Gleicher N. Utilization of third-party in vitro fertilization in the United States. Am J Obstet Gynecol. 2016 Nov 14. pii: S0002-9378(16)32019-1. doi: 10.1016/j.ajog.2016.11.1022.
Gleicher, N.,Kushnir, V. A.,Sen, A.,Darmon, S. K.,Weghofer, A.,Wu, Y. G.,Wang, Q.,Zhang, Albertini, D. F.,Barad, D. H.Definition by FSH, AMH and embryo numbers of good-, intermediate- and poor-prognosis patients suggests previously unknown IVF outcome-determining factor associated with AMH. J Transl Med. 2016 Jun 10;14(1):172. doi: 10.1186/s12967-016-0924.
Gleicher, N. Vidali, A. Braverman, J. Kushnir, V.A. Barad, D.B., Hudson, C., Wu, Y.-G, Wang, Q., Zhang, L., Albertini, D.F. 2016. Accuracy of preimplantation genetic screening (PGS) is compromised by degree of mosaicism of human embryos. Reprod. Biol. Endocr. 14:54 DOI 10.1186/s12958-016-0193-6.
Albertini, D.F. and Telfer, E.E.2016. Deconstructing the winding path to the recapitulation of mammalian oogenesis ex vivo. . Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):9956-7. doi: 10.1073/pnas.1610646113.
Bebbere, D. Masala, L. Albertini, D.F. and Ledda, S. 2016. The subcortical maternal complex: multiple functions for one biological structure? J Assist Reprod Genet. //www.ncbi.nlm.nih.gov/pubmed/27525657
Gleicher, N. Kushnir, V. Albertini, D.F. and Barad, D.H. 2016. Improvements in IVF in women of advanced age. J Endocrinol. 2016 Jul;230(1):F1-6. doi: 10.1530. //www.ncbi.nlm.nih.gov/pubmed/27154334
Linck, R.W., Chemes, H.E. and Albertini, D.F. 2016 The axoneme: the propulsive engine of spermatozoa and cilia and associated ciliopathies leading to infertility
J Assist Reprod Genet. 2016 Jan 29. DOI 10.1007/s10815-0160652 //www.ncbi.nlm.nih.gov/pubmed/26825807
Bogliolo, L.,Murrone, O.,Piccinini,M.,Ariu, F.,Ledda, S.,Tilocca, S., and Albertini, D. F (2015) Evaluation of the impact of vitrification on the actin cytoskeleton of in vitro matured ovine oocytes by means of Raman microspectroscopy J Assist Reprod Genet. Feb;32(2):185-93. doi: 10.1007/s10815-014-0389-7. Epub 2014 Nov 16.
Sanfins, A.,Plancha, C. E., and Albertini, D. F. (2015) Pre-implantation developmental potential from in vivo and in vitro matured mouse oocytes: a cytoskeletal perspective on oocyte quality. J Assist Reprod Genet. 2015 Jan;32(1):127-36. doi: 10.1007/s10815-014-0363-4. Epub 2014 Nov 9.
Albertini, N Gleicher (2015) A detour in the quest for oogonial stem cells: why methods matter. Nat Med 21(10):1126-7.
Lazzaroni-Tealdi E, Barad DH, Albertini DF, Yu Y, Kushnir VA, Russell H, Wu YG, Gleicher N. (2015) Oocyte scoring enhances embryo-scoring in predicting pregnancy chances with IVF where it counts most. PLoS ONE 10(12:e014362.
Wu, Y. G., Barad, D. H,. Kushnir, V. A., Lazzaroni, E., Wang, Q., Albertini, D. F,. and Gleicher, N. (2015). Aging-related premature luteinization of granulosa cells is avoided by early oocyte retrieval. J Endocrinol. 226:167-80. doi: 10.1530/JOE-15-0246. //www.ncbi.nlm.nih.gov/pubmed/26264981
Coticchio, G, Dal Canto, M., Guglielmo, M. C., Albertini, D. F.,Mignini Renzini, M.,Merola, M., Lain, M.,Sottocornola, M.,De Ponti, E., Fadini, R. (2015). Double-strand DNA breaks and repair response in human immature oocytes and their relevance to meiotic resumption. J Assist Reprod Genet. 2015 Aug 4.
//www.ncbi.nlm.nih.gov/pubmed/26238391
Kushnir, V. A.,Halevy, N., Barad, D. H., Albertini, D. F. and Gleicher, N. (2015) Relative importance of AMH and androgens changes with aging among non-obese women with polycystic ovary syndrome. J Ovarian Res.8(1):45. doi: 10.1186/s13048-015-0175-x.//www.ncbi.nlm.nih.gov/pubmed/26156856
Wu YG, Barad DH, Kushnir VA, Lazzaroni E, Wang Q, Albertini DF, Gleicher N. Aging-related premature luteinization of granulosa cells is avoided by early oocyte retrieval. J Endocrinol 2015;226(3)):167-80.
Gleicher N, Vega, Darmon SK, Weghofer A, Barad DH, Wu YG, Wang Q, Zhang L, Albertini D, Kushnir VA. Live-birth rates in very poor prognosis patients who are defined as poor responders under the Bologna criteria with nonelective single embryo, two-embryo, and three or more embryos transferred. Fertil Steril 2015;104(6):1435-41.
Franciosi, F., Coticchio, G., Lodde, V., Tessaro, I., Modina, SC., Fadini, R., Dal Canto, B., Renzini, MM., Albertini, DF., Luciano, AM. (2014). Natriuretic Peptide Precursor C Delays Meiotic Resumption and Sustains Gap Junction-Mediated Communication in Bovine Cumulus-Enclosed Oocytes. Biol. Reprod. 91:1-9. DOI 10.1095/biolreprod.114.118869
Coticchio, G, Gugliemo, M.C., Albertini, D.F., Dal Canto, M., Mignini Renzini, M. De Ponti, E. Fadini, R. (2014). Contributions of the actin cytoskeleton to the emergence of polarity during maturation in human oocytes. Molec. Human Reprod. 20:200-207. (10.1093/molehr/gat085)
Anderson, R.A., McLaughlin, M., Wallace, W.H.B., Albertini, D.F., Telfer, E.E. (2014). The immature human ovary shows loss of abnormal follicles and increasing follicle developmental competence through childhood and adolescence. Human Reprod. 29: 97-106. (10.1093/humrep/det388)
Yesilaltay A, G. Dokshina, D. Bussoc, L. Wanga, D. Galianid, T. Chavarriae, E. Vasilef,
L.Quilaqueoc, J. Orellanag, D.Walzera, R. Shalgi, N. Dekel, D.F.Albertini,A.Rigotti,
D.C.Page, and M. Krieger (2014). Excess cholesterol induces mouse egg activation and may cause female infertility. Proc. Nat. Acad. Sci. (USA)
www.pnas.org/cgi/doi/10.1073/pnas.1418954111
Albertini, D.F. The Mammalian Oocyte. In, Knobil and Neill’s Physiology of Reproduction, Editors-in-Chief Tony M. Plant and Anthony J. Zeleznik, 4th edition doi.org/10.1016/B978-0 12-397175-3.00002-8
Dieci, C, Lodde, V., Franciosi, F., Albertini, D.F., Lazzari, G., Galli, C., and Luciano, A.M. (2013).The effect of cilostamide on gap junction communication dynamics,chromatin remodeling, and competence acquisition in pig oocytes following parthenogenetic activation and nuclear transfer. Biol. Reprod. 89:68-75. ( DOI:10.1095/biolreprod.113.110577)
Coticchio, G. Gugliemo, M.C., Dal Canto, M., Fadini, R., Renzini, M., DePonti, E., Brambillasca, F., and Albertini, D.F. (2013). Mechanistic foundations of the metaphase II spindle of human oocytes matured in vivo and in vitro. Human Reprod. 28:3271-3282. (10.1093/humrep/det381)
Fulka, Jr., J., Langerova, A., Loi, P., Ptak, G., Albertini, D.F., and Fulka, H. (2013) The ups and downs of somatic cell nucleus transfer (SCNT) in humans. J. Assist. Reprod. Genetics 30:1055-8. ( DOI 10.1007/s10815-013-0053-7)
Li, R and Albertini, DF ( 2013) The road to maturation: somatic cell interaction and self-organization of the mammalian oocyte. Nature Reviews Molecular Cell Biology 14: 141-152. (doi:10.1038/nrm3531).
McGinnis LK, Limback SD, Albertini DF (2013) Signaling modalities during oogenesis in mammals. In P M Wassarman, editor: Current Topics in Developmental Biology, Vol. 102,Academic Press, pp. 227-242. (ISBN: 978-0-12-416024-8).
Combelles, C.M.H. and Albertini, D.F. (2012).Over 40 years of mentoring, educating, and researching in the world of oocytes. An interview with Professor Albertini. Int. J. Devel. Biol. 56:765-770. (doi: 10.1387/ijdb.120176cc)
Telfer E E and Albertini, DF (2012).The quest for human ovarian stem cells. Nature Medicine 18:353-354.
Albertini, DF (2012). Oocyte In Vitro Maturation: Formidable Obstacles on the Road to Fertility Preservation”, In: Fertility Preservation, Eds. Seli, E., and Agarwal, A. Springer, London Ch. 10,pp121-128.
So IH, Hodges CA, Albertini DF, Hunt PA. (2011). Oocyte-specific differences in cell cycle control create an innate susceptibility to meiotic errors. Current Biology 21:651-657 DOI 10.1016/j.cub.2011.03.003
Petroff, B Valdez, K.Brown, SB, Piasecka, J and Albertini, DF. (2011). The aryl hydrocarbon receptor agonist 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) alters early embryonic development in a rat IVF exposure model. Reprod. Toxicol. 32:286-292.
McGinnis, L. K., & Albertini, D. F. (2010). Dynamics of protein phosphorylation during
meiotic maturation. J. Assisted Reprod. Genetics, 27, 169–182.
Hutt KJ, Shi Z, Petroff BK, Albertini DF. (2010). The environmental toxicant 2,3,7,8 tetrachlorodibenzo-p-dioxin disturbs the establishment and maintenance of cell polarity in preimplantation rat embryos. Biol. Reprod. 82: 914-920. PMCID: PMC 2857633.
Barrett SL, Albertini DF. (2010). Cumulus cell contact during oocyte maturation in mice regulates meiotic spindle positioning and enhances developmental competence. J Assist Reprod Genet. 27:29-39. PMCID: PMC2826619.
McLaughlin M, Bromfield JJ, Albertini DF, Telfer EE..2010 Activin promotes follicular integrity and oogenesis in cultured pre-antral bovine follicles. Mol Hum Reprod. 16:644-53.PubMed PMID: 20203128
Coticchio G, Sciajno R, Hutt K, Bromfield J, Borini A, Albertini DF. 2010 Comparative analysis of the metaphase II spindle of human oocytes through polarized light and high-performance confocal microscopy. Fertil Steril. 93:2056-64. PMID: 19243751.
Invited Lectures (>200 around the globe)
Most all 2020 lectures delivered via Zoom: links available
https://www.youtube.com/watch?v=GSjpLV0TGxY
https://www.youtube.com/watch?v=M7SsD9J26E0
//comm.archive.mbl.edu/news/features/feature_fir_symp.html
https://www.youtube.com/watch?app=desktop&v=xMFyqtnTLcE
https://www.youtube.com/watch?v=5y8a7z_qfCs
Some past lectures representing the range of topics Professor Albertini is often asked to lecture on:
Clinical relevance of oocyte mitochondria. Pacific Coast Reproduction Society Annual Meeting, Indian Wells CA March 22-26.
Embryo selection approaches today and in the future. AAB Symposium, Houston, TX May 18-20.
Cumulus-oocyte communication determined embryo competence through multiple signaling pathways: A Mother’s legacy. ESHRE Pre-Congress Symposium, Geneva Switzerland July 1-3.
The oocyte as the mother of all cells. How the bovine model of IVM informs human ARTs. Brazilian Society for Embryo Technology August 17-19.
Revisiting the ovarian stroma: more than a holding zone for the follicle. Ovarian Club VIII, Barcelona, Spain. September 15-18.
The precarious role of the cell cycle in the propagation of aneuploidy in human embryos. 19th World Congress on In Vitro Fertilization. October 4-7.
“How regenerative medicine is changing the face of reproductive medicine.” D.H.Barron Lectureship, University of Florida, Gainesville, FL December 7, 2016.
“Are we intervening too late with embryo selection for human IVF?” and “Clinical utilization of reproductive organ stem cells.” Foundation for Reproductive Medicine Symposium. New York City, November 17-20.
“How signaling modalities link oogenesis to embryogenesis” Ovarian Club VII, Paris, France, November 5, 2016.
“What embryologists already knew: The charade that is PGS.” New England Assisted Reproductive Technologists Meeting.Brigham and Women’s Hospital, Boston, MA, September 26, 2016.
“A historical overview of oocyte maturation.” ESHRE Workshop on Oocyte Maturation From Basics To Clinics. Brussels, Belgium, March 3, 2016.
“A symbiotic perspective of the differences between in vivo and in vitro maturation in mammalian oocytes.” ESHRE Workshop on Oocyte Maturation From Basics To Clinics. Brussels, Belgium, March 3, 2016.
“Integrating oogenesis with folliculogenesis: building a functional syncytium.” ESHRE Annual Meeing. Helsinki, Finland, July 4, 2016.
“Aneuploidy in human gametes and embryos: when appearances are deceiving. ” Council of Physicians and Scientists Annual Meeting, Austin, TX. May 5, 2016.
“Tracing embryo quality parameters to their origins in gametogenesis.” Council of Physicians and Scientists Annual Meeting, Austin, TX. May 6, 2016.
“Tracking time during human development.” Voyager’s Lecture, KU Medical Center, KC, KS, May 16, 2016.
“Ovarian germline stem cells: background, current status, and future directions.” Southwest Embryology Summit , Caesar’s Palace, Las Vegas, NV January 4, 2016.
“The oocyte as a unique cell.” International Society for Fertility Preservation Symposium, Brussels, Belgium, January 16, 2015
“Building an ovary is a complicated matter.” ESHRE Workshop on Development of the Mammalian Gonad, Muenster, Germany February 15, 2015
“Mitochondria, maternal inheritance, and sexual dimorphism in the mammalian gametes.” ESHRE Workshop on gender-related disease risks. Capri, Italy August 28, 2015.
“Genomic plasticity and the sex chromosomes: is the Y chromosome a wasteland?” ESHRE Workshop on gender-related disease risks. Capri, Italy August 28, 2015.
“Genetic and epigenetic determinants of human embryo quality.” Symposium on The Future of Human ARTS, Ragusa, Italy, September 17, 2015.
“Aneuploidy as a driving force in early human development.” Magee Institute for Women’s Research, University of Pittsburgh, PA, October 6, 2015.
“Bioenergetics of cytokinesis and karyokinesis in the preimplantation human embryo.” 7th Annual Ovarian Club Meeting, Barcelona, Spain November 14, 2015.
“Developmental competence of the oocyte-follicle unit.” American Society for Reproductive Medicine Grand Rounds, Webcast from Kansas City. December, 5, 2015.
“The problem of egg quality-What makes a good egg?”and ”Updates on Fertility Preservation,” Association of Clinical Embryologists, Sheffield England, January 4-6.
“Biology of the ovarian reserve” and “Ovarian Stem Cells: facts and fallacies,” Updates in Infertility Treatments, Ferring Inc. Prague, Czech Republic, January 23-26.
“Human ARTs-the next generation,” Reproductive Medical Associates, New York, June 11.
“The connection between maternal health, oocyte quality, and offspring produced by human ARTs,” IBSA Symposium on the future of human ARTs. European Society for Human Reproduction and Embryology (ESHRE), Munich Germany, June 30.
“Is aneuploidy so bad for human embryos afterall?”, Aneuploidy Symposium, Canadian Fertility and Andrology Society, Quebec City, Canada, September 13.
“New insights into the biology of the ovarian reserve,” and “Revisiting the mechanism of LH-induced oocyte maturation: more questions than answers.” Tecnobios Procreazione Symposium, Rome Italy, October 9-12.
“Gateways to success: the sperms’ perspective for finding and penetrating the egg,” Society for Male Reproduction and Urology Symposium, American Society for Reproductive Medicine annual meeting; Honolulu, Hawaii October 21.
“Genetic instability in human embryos: origins and consequences,” Ovarian Club IV Meeting, Paris, France, November 14.
“Ovarian Physiology in 2014-A changing landscape,” Grand Rounds, The Center for Human Reproduction, New York, NY, November 25.
”Mechanisms of DNA Damage and Repair”, Fertility Preservation and Cancer Symposium, Hong Kong, Feb 1
“Advances in human oocyte in vitro maturation” Fertility Preservation and Cancer Symposium, Hong Kong, Feb 3
“Linking oocyte and embryo quality in the practice of human ARTs” Fertility Society of Mumbai,Mumbai India (via SKYPE) Feb 12
“In vitro maturation of eggs and follicles”, ASRM-ESHRE Symposium on Reproductive Medicine:The Future, Nassau, Bahamas, March 7
“How advances in reproductive physiology are making a difference in human ARTs”, 3rd Symposium of the International Society for Mild Approaches in Assisted Reproduction, Nanjing, China, March 24
“In Vitro Oocyte Maturation in the Treatment of Human Infertility. Department of Reproductive Medicine of Renji Hospital, Shanghai Jiao Tong University School of Medicine, March 26, Shanghai China.
“Maintaining genetic integrity in the female germ line.” Animal Research and Biotechnology Institute, Colorado State University, April 9, Fort Collins, CO.
“In search of the perfect egg.” Beacon Lecture, Frontiers in Reproduction Symposium, MBL, Woods Hole, MA June 8.
“Do ovarian germ line stem cells exist in mammals?” Session Chair and lecturer, Gordon Research Conference on Germinal Stem Cell Biology, Chinese University of Hong Kong, Hong Kong, July 15-19.
“Newborn health and oocyte legacy,” and “Cell cycle control in human embryos: why all the aneuploidy?”. ESHRE Capri Workshop on Birth Defects Revisited: Causes and Consequences; September 1-2.
“How basic science advances are optimizing human ARTs.” ObGyn Grand Rounds, UMASS Memorial Hospital, Dept. OB/GYN, Worcester MA September 11.
“Mechanisms underlying surveillance and maintenance of genomic integrity in the female germ line of mammals.” Department of Cell Biology. UMASS Medical Center, Worcester, MA. September 11.
“Stem cells and neo-oogenesis in mammals” , “Human oocyte in vitro maturation-where do we stand for clinical application?” “Effects of chemotherapy and radiotherapy on female gonadal function and germ cells.” Oncofertility Symposium, Center for Genetics and Reproduction, CEGYR. Buenos Aires, Argentina. October 3,4.
“The magical mystery tour from primordial to antral follicle-role of the ovarian stroma.” Ovarian Club III. Paris, France. November 16.
“Testing the genetic integrity of oocytes derived from stem cells” (Nov 9), “Cell cycle control in human embryos-Why all the aneuploidy?” (Nov 11), Ovarian Club II, Prague.
“From within and without: how ovarian somatic cells influence oocyte quality during aging”, NIH-ASRM Joint Workshop on the Ovarian Reserve, San Diego, October 22
“Overview of cryobiology in the field of fertility preservation”, Big Chill Symposium, American Society for Reproductive Medicine, San Diego, October 20
“Follicle quality and chances to pregnancy: The Researcher’s Viewpoint”, Serono Symposium Honoring Jacques Donnez, Brussels, Belgium, September 20
“Coordinating oogenesis and folliculogenesis”, Japanese Society for Fertility and Infertility, Osaka, Japan, August 29
“Maintaining follicle integrity after cryopreservation and culture”, Symposium on Basic Science and fertility Preservation, Asian South Pacific Initiative for Reproduction and Embryology (ASPIRE) 2nd Annual Meeting, Osaka, Japan, August 31
“Human oocyte cryopreservation-the science behind the technology”, Society for the Study of Reproduction Annual Meeting, Penn. State University, Happy Valley PA, August 10
“Coordinating oogenesis and folliculogenesis to obtain high quality oocytes”, “Cell cycle checkpoint control in oocytes and embryos”, and “Imaging strategies for gametes and embryos”, Visiting Professor Lectureship Series in Reproductive Physiology, University of Sassari, College of Veterinary Medicine, Sardinia, Italy, June 13, 19, and 20
“Maintaining genome integrity in mammalian oocytes”, Dept. Anatomy and cell Biology, New York medical College, Valhalla, N.Y. May 9
“Should elective oocyte cryopreservation be offered to young women”, and “The basic science of oocyte cryopreservation” New England Fertility Society, Portland ME, April 27,28
“Genome integrity in mammalian oocytes”, ESHRE Workshop on Oogenesis and Folliculogenesis, Stresa Italy, April 19
”New perspectives on genetic stability in mammalian oocytes”, Reproduction Medicine Associates, Department of Obstetrics and Gynecology, Rutgers University, Morristown, N.J. April 5
“Empowering female germ cells with developmental potential”, Department of veterinary Science, Cornell University, Ithaca, N.Y. April 4
“Oocyte stem cells-An update”, NYU Fertility Center, Department of Obstetrics and Gynecology, NYU Medical Center, New York, N.Y. April 3
“Determinants of oocyte quality for fertility preservation-beyond the big chill”, The Oncofertility Consortium Virtual Grand Rounds, Northwestern University, Chicago IL, February 9
“How do human oocytes maintain genetic stability?”, Grand Rounds, The Center for Human Reproduction, New York, N.Y. February 7
https://link.springer.com/journal/10815/34/2?wt_mc=alerts.TOCjournals
//www.the-scientist.com/?articles.view/articleNo/47256/title/From-Stem-Cell-to-Oocyte-In-a-Dish/
//www.nature.com/news/gene-editing-research-in-human-embryos-gains-momentum-1.19767.
//www.springer.com/medicine/gynecology/book/978-0-85729-825-6
//link.springer.com/search?facet-author=%22David+F.+Albertini%22
//www.nytimes.com/2012/02/27/health/research/scientists-use-stem-cells-to-generate-human-eggs.html
//news.sciencemag.org/sciencenow/2012/02/human-egg-stem-cells-isolated.html
//link.springer.com/journal/10815#
//www.slideshare.net/Research_Instruments/ovarian-germline-stem-cells-david-f-albertini-phd
//www.bionews.org.uk/page_711812.asp
https://www.theguardian.com/science/2016/oct/07/evidence-suggests-womens-ovaries-can-grow-new-eggs
//www.the-scientist.com/?articles.view/articleNo/47256/title/From-Stem-Cell-to-Oocyte-In-a-Dish/
https://link.springer.com/article/10.1007/s10815-017-0878-6